Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea

被引：31

作者：

Vongvanich, Namphung

Kittakoop, Prasat

Charoenchai, Panarat

Intamas, Sutichai

Sriklung, Kanlayanee

Thebtaranonth, Yodhathai

机构：

[1] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10700, Thailand

[2] NSTDA, Natl Ctr Genet Engn & Biotechnol, Klongluang, Pathumthani, Thailand

来源：

PLANTA MEDICA | 2006年 / 72卷 / 15期

关键词：

D O I：

10.1055/s-2006-951711

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical exploration of Carrichaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1 9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCl-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCl-H187 and BC cell lines, however the ester 10 showed only mild anti mycobacterial activity.

引用

页码：1427 / 1430

页数：4

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