Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea

被引：31
|
作者：
Vongvanich, Namphung
Kittakoop, Prasat
Charoenchai, Panarat
Intamas, Sutichai
Sriklung, Kanlayanee
Thebtaranonth, Yodhathai
机构：
[1] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10700, Thailand
[2] NSTDA, Natl Ctr Genet Engn & Biotechnol, Klongluang, Pathumthani, Thailand
来源：
PLANTA MEDICA | 2006年 / 72卷 / 15期
关键词：
D O I：
10.1055/s-2006-951711
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Chemical exploration of Carrichaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1 9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCl-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCl-H187 and BC cell lines, however the ester 10 showed only mild anti mycobacterial activity.
引用
收藏
页码：1427 / 1430
页数：4
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