Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells

被引：62
|
作者：
Lucas, M
Day, CL
Wyer, JR
Cunliffe, SL
Loughry, A
McMichael, AJ
Klenerman, P
机构：
[1] Univ Oxford, Nuffield Dept Med, Oxford OX1 3SY, England
[2] John Radcliffe Hosp, WIMM, MRC, Human Immunol Unit, Oxford, England
来源：
JOURNAL OF VIROLOGY | 2004年 / 78卷 / 13期
关键词：
D O I：
10.1128/JVI.78.13.7284-7287.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a prototype response to a nonpersistent pathogen, we have used such techniques to analyze influenza virus-specific memory CD4 T cells directly from blood. These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct "central memory" CD62L(+) phenotype.
引用
收藏
页码：7284 / 7287
页数：4
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