Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells

被引：62
|
作者：
Lucas, M
Day, CL
Wyer, JR
Cunliffe, SL
Loughry, A
McMichael, AJ
Klenerman, P
机构：
[1] Univ Oxford, Nuffield Dept Med, Oxford OX1 3SY, England
[2] John Radcliffe Hosp, WIMM, MRC, Human Immunol Unit, Oxford, England
来源：
JOURNAL OF VIROLOGY | 2004年 / 78卷 / 13期
关键词：
D O I：
10.1128/JVI.78.13.7284-7287.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a prototype response to a nonpersistent pathogen, we have used such techniques to analyze influenza virus-specific memory CD4 T cells directly from blood. These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct "central memory" CD62L(+) phenotype.
引用
收藏
页码：7284 / 7287
页数：4
相关论文
共 50 条
  • [1] Quantitative analysis of the influenza virus-specific CD4(+) T cell memory in the absence of B cells and Ig
    Topham, DJ
    Tripp, RA
    HamiltonEaston, AM
    Sarawar, SR
    Doherty, PC
    [J]. JOURNAL OF IMMUNOLOGY, 1996, 157 (07): : 2947 - 2952
  • [2] PREVALENCE AND ACTIVATION PHENOTYPE OF SENDAI VIRUS-SPECIFIC CD4(+) T-CELLS
    EWING, C
    TOPHAM, DJ
    DOHERTY, PC
    [J]. VIROLOGY, 1995, 210 (01) : 179 - 185
  • [3] Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells
    Lanzer, Kathleen G.
    Johnson, Lawrence L.
    Woodland, David L.
    Blackman, Marcia A.
    [J]. IMMUNITY & AGEING, 2014, 11
  • [4] Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells
    Kathleen G Lanzer
    Lawrence L Johnson
    David L Woodland
    Marcia A Blackman
    [J]. Immunity & Ageing, 11
  • [5] An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8+ T cells
    Stambas, John
    Doherty, Peter C.
    Turner, Stephen J.
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (03): : 1285 - 1292
  • [6] Role of TNFα in regulation of virus-specific CD4 T cells
    Singh, A
    Suresh, M
    [J]. FASEB JOURNAL, 2005, 19 (04): : A406 - A406
  • [7] Memory CD4 T Cells in Influenza
    Zens, Kyra D.
    Farber, Donna L.
    [J]. INFLUENZA PATHOGENESIS AND CONTROL - VOL II, 2015, 386 : 399 - 421
  • [8] Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults
    Su, Laura F.
    Kidd, Brian A.
    Han, Arnold
    Kotzin, Jonathan J.
    Davis, Mark M.
    [J]. IMMUNITY, 2013, 38 (02) : 373 - 383
  • [9] Radiation causes long term changes in virus-specific and virtual memory CD4 T cells
    Kannan, Shravan Kumar
    Heidarian, Mohammad
    Swanson, Whitney
    Griffith, Thomas S.
    Harty, John T.
    Badovinac, Vladimir P.
    [J]. JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [10] Establishment and persistence of virus-specific CD4(+) and CD8(+) T cell memory
    Doherty, PC
    Topham, DJ
    Tripp, RA
    [J]. IMMUNOLOGICAL REVIEWS, 1996, 150 : 23 - 44
12345