1,2,3-Triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines

被引：10

作者：

Biagi, G ^{[1
]}

Giorgi, I ^{[1
]}

Livi, O ^{[1
]}

Manera, C ^{[1
]}

Scartoni, V ^{[1
]}

机构：

[1] Univ Pisa, Fac Farm, Dipartimento Sci Farmaceut, I-56126 Pisa, Italy

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1999年 / 36卷 / 05期

关键词：

D O I：

10.1002/jhet.5570360514

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Some new 1,2,3-triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines were prepared starting from the corresponding 1,2,3-triazolo [4,5-d]pyrimidines via the formation of the 1,2,4-triazole ring. Thus suitable hydrazino derivatives 6 were condensed with triethyl orthoformate, triethyl orthoacetate and triethyl orthobenzoate to give the expected tricyclic derivatives 7, 8 and 9. Intramolecular cyclization of the ethoxycarbonylhydrazino derivatives 10 gave the tricyclic compounds 11 bearing an hydroxyl group in the 3 position. The v-triazolo-s-triazolopyrimidine derivatives were tested towards the Al and AZA adenosine receptors in binding assays, but they did not show any receptor affinity.

引用

页码：1195 / 1198

页数：4

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