1,2,3-Triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines

被引：10
|
作者：
Biagi, G [1 ]
Giorgi, I [1 ]
Livi, O [1 ]
Manera, C [1 ]
Scartoni, V [1 ]
机构：
[1] Univ Pisa, Fac Farm, Dipartimento Sci Farmaceut, I-56126 Pisa, Italy
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1999年 / 36卷 / 05期
关键词：
D O I：
10.1002/jhet.5570360514
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some new 1,2,3-triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines were prepared starting from the corresponding 1,2,3-triazolo [4,5-d]pyrimidines via the formation of the 1,2,4-triazole ring. Thus suitable hydrazino derivatives 6 were condensed with triethyl orthoformate, triethyl orthoacetate and triethyl orthobenzoate to give the expected tricyclic derivatives 7, 8 and 9. Intramolecular cyclization of the ethoxycarbonylhydrazino derivatives 10 gave the tricyclic compounds 11 bearing an hydroxyl group in the 3 position. The v-triazolo-s-triazolopyrimidine derivatives were tested towards the Al and AZA adenosine receptors in binding assays, but they did not show any receptor affinity.
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收藏
页码：1195 / 1198
页数：4
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