Not just amyloid: physiological functions of the amyloid precursor protein family

被引：423

作者：

Mueller, Ulrike C. ^{[1
]}

Deller, Thomas ^{[2
]}

Korte, Martin ^{[3
,4
]}

机构：

[1] Heidelberg Univ, Inst Pharm & Mol Biotechnol, Bioinformat & Funct Genom, Neuenheimer Feld 364, D-69120 Heidelberg, Germany

[2] Goethe Univ Frankfurt, Inst Clin Neuroanat, Neurosci Ctr, Theodor Stern Kai 7, D-60590 Frankfurt, Germany

[3] TU Braunschweig, Zool Inst, Cellular Neurobiol, Spielmannstr 7, D-38106 Raunschweig, Germany

[4] Helmholtz Ctr Infect Res, Neuroinflammat & Neurodegenerat Grp, Inhoffenstr 7, D-38124 Braunschweig, Germany

来源：

NATURE REVIEWS NEUROSCIENCE | 2017年 / 18卷 / 05期

关键词：

TRAUMATIC BRAIN-INJURY; LONG-TERM POTENTIATION; HIPPOCAMPAL SYNAPTIC PLASTICITY; RIBOSYLATION FACTOR 6; BETA-PP-ALPHA; ALZHEIMERS-DISEASE; MICE LACKING; APPS-ALPHA; CRYSTAL-STRUCTURE; GENE-EXPRESSION;

D O I：

10.1038/nrn.2017.29

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amyloid precursor protein (APP) gives rise to the amyloid-beta peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood. Studying these physiological functions has been challenging and has required a careful long-term strategy, including the analysis of different App-knockout and Aplp-knockout mice. In this Review, we summarize these findings, focusing on the in vivo roles of APP family members and their processing products for CNS development, synapse formation and function, brain injury and neuroprotection, as well as ageing. In addition, we discuss the implications of APP physiology for therapeutic approaches.

引用

页码：281 / 298

页数：18

共 50 条

[21] Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers
Gralle, Matthias
Botelho, Michelle Gralle
Wouters, Fred S.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (22) : 15016 - 15025
[22] Alzheimer's disease:: Physiological and pathogenetic role of the amyloid precursor protein (APP), its Aβ-amyloid domain and free Aβ-amyloid peptide
Beyreuther, K
Master, CL
NEURODEGENERATIVE DISORDERS: LOSS OF FUNCTION THROUGH GAIN OF FUNCTION, 2001, : 97 - 117
[23] Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy
Grabowski, TJ
Cho, HS
Vonsattel, JPG
Rebeck, GW
Greenberg, SM
ANNALS OF NEUROLOGY, 2001, 49 (06) : 697 - 705
[24] Proteolytic processing and cell biological functions of the amyloid precursor protein
De Strooper, B
Annaert, W
JOURNAL OF CELL SCIENCE, 2000, 113 (11) : 1857 - 1870
[25] Oxidation of cholesterol by amyloid precursor protein and β-amyloid peptide
Nelson, TJ
Alkon, DL
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (08) : 7377 - 7387
[26] Interactions between amyloid, amyloid precursor protein, and mitochondria
Wilkins, Heather M.
BIOCHEMICAL SOCIETY TRANSACTIONS, 2023, 51 (01) : 173 - 182
[27] Sulfuretin exerts diversified functions in the processing of amyloid precursor protein
Chen, Jian
Luo, Biao
Zhong, Bi-Rou
Li, Kun-Yi
Wen, Qi-Xin
Song, Li
Xiang, Xiao-Jiao
Zhou, Gui-Feng
Hu, Li-Tian
Deng, Xiao-Juan
Ma, Yuan-Lin
Chen, Guo-Jun
GENES & DISEASES, 2021, 8 (06) : 867 - 881
[28] Cellular Functions of the Amyloid Precursor Protein from Development to Dementia
van der Kant, Rik
Goldstein, Lawrence S. B.
DEVELOPMENTAL CELL, 2015, 32 (04) : 502 - 515
[29] Processing of amyloid precursor protein and amyloid peptide neurotoxicity
Nathalie, Pierrot
Jean-Noel, Octave
CURRENT ALZHEIMER RESEARCH, 2008, 5 (02) : 92 - 99
[30] The crystal structure of amyloid precursor-like protein 2 E2 domain completes the amyloid precursor protein family
Roisman, Laila C.
Han, Sen
Chuei, Mun Joo
Connor, Andrea R.
Cappai, Roberto
FASEB JOURNAL, 2019, 33 (04): : 5076 - 5081

← 1 2 3 4 5 →