From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

被引：25

作者：

Desrat, S. ^{[1
]}

Remeur, C. ^{[1
]}

Geny, C. ^{[1
]}

Riviere, G. ^{[1
]}

Colas, C. ^{[1
]}

Dumontet, V. ^{[1
]}

Birlirakis, N. ^{[1
]}

Iorga, B. I. ^{[1
]}

Roussi, F. ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, CNRS UPR 2301, F-91198 Gif Sur Yvette, France

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 62期

关键词：

DERIVATIVES; FAMILY; EXPLORATION; DISCOVERY;

D O I：

10.1039/c4cc01830c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of one of the most potent dual inhibitors of the antiapoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps.

引用

页码：8593 / 8596

页数：4

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