Cutaneous and Visceral Chronic Granulomatous Disease Triggered by a Rubella Virus Vaccine Strain in Children With Primary Immunodeficiencies

被引:54
|
作者
Neven, Benedicte [1 ,2 ,3 ]
Perot, Philippe [9 ,10 ]
Bruneau, Julie [3 ]
Pasquet, Marlene
Ramirez, Marie [12 ]
Diana, Jean-Sebastien [1 ,2 ]
Luzi, Stephanie [4 ]
Corre-Catelin, Nicole [11 ]
Chardot, Christophe [5 ]
Moshous, Despina [1 ,2 ]
Mercier, Stephanie Leclerc [3 ,4 ,6 ]
Mahlaoui, Nizar [2 ]
Aladjidi, Nathalie [13 ]
Le Bail, Brigitte [14 ]
Lecuit, Marc [1 ,7 ,8 ,9 ]
Bodemer, Christine [6 ]
Molina, Thierry Jo [1 ,3 ]
Blanche, Stephane [1 ,2 ]
Eloit, Marc [9 ]
机构
[1] Paris Descartes Univ, Inst Imagine, Sorbonne Paris Cite, Paris, France
[2] Hop Necker Enfants Malad, AP HP, Paediat Haematoimmunol Unit, Paris, France
[3] Hop Necker Enfants Malad, AP HP, Dept Pathol, Paris, France
[4] Hop Necker Enfants Malad, AP HP, Dept Radiol, Paris, France
[5] Hop Necker Enfants Malad, AP HP, Dept Pediat Surg, Paris, France
[6] Hop Necker Enfants Malad, AP HP, Dept Dermatol, Paris, France
[7] Hop Necker Enfants Malad, AP HP, Dept Infect Dis, Paris, France
[8] Natl Reference Ctr Primary Immune Deficiencies, Paris, France
[9] INSERM, Lab Pathogen Discovery, Biol Infect Unit, U1117, 28 Rue Docteur Roux, F-75015 Paris, France
[10] Ctr Innovat & Rech Technol, Biom, Paris, France
[11] Inst Pasteur, Invest Clin & Acces Ressources Biolog, Paris, France
[12] CHU Toulouse, Ctr Res Cancerol Toulouse, Inst Univ Canc Toulouse Oncopole, Hematol & Immunol Pediat Dept,Team 16, Toulouse, France
[13] Univ Hosp Bordeaux, Pediat Hosp, INSERM,CEREVANCE,CIC 1401, Ctr Invest Clin Plurithemat,Pediat Oncol Hematol, Bordeaux, France
[14] Hop Enfants Hop Pellegrin, Dept Pathol, Bordeaux, France
关键词
rubella; granuloma; skin; spleen; vaccine; RAG MUTATIONS;
D O I
10.1093/cid/ciw675
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Persistence of rubella live vaccine has been associated with chronic skin granuloma in 3 children with primary immunodeficiency. We describe 6 additional children with these findings, including 1 with visceral extension to the spleen.
引用
收藏
页码:83 / 86
页数:4
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