Potential Targets for Antifungal Drug Discovery Based on Growth and Virulence in Candida albicans

被引：34

作者：

Li, Xiuyun ^{[1
]}

Hou, Yinglong ^{[2
]}

Yue, Longtao ^{[3
]}

Liu, Shuyuan ^{[1
]}

Du, Juan ^{[3
]}

Sun, Shujuan ^{[4
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250100, Shandong, Peoples R China

[2] Shandong Univ, Qianfoshan Hosp, Dept Cardiol, Jinan 250100, Shandong, Peoples R China

[3] Shandong Univ, Qianfoshan Hosp, Translat Med Res Ctr, Jinan 250100, Shandong, Peoples R China

[4] Shandong Univ, Dept Pharm, Qianfoshan Hosp, Jinan 250100, Shandong, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 10期

关键词：

OXIDATIVE STRESS-RESPONSE; PROTEIN-KINASE PATHWAY; TRANSCRIPTION FACTOR; HYPHAL DEVELOPMENT; BIOFILM FORMATION; GLYOXYLATE CYCLE; ISOCITRATE LYASE; INVASIVE CANDIDIASIS; SIGNALING PATHWAY; CYCLOSPORINE-A;

D O I：

10.1128/AAC.00726-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fungal infections, especially infections caused by Candida albicans, remain a challenging problem in clinical settings. Despite the development of more-effective antifungal drugs, their application is limited for various reasons. Thus, alternative treatments with drugs aimed at novel targets in C. albicans are needed. Knowledge of growth and virulence in fungal cells is essential not only to understand their pathogenic mechanisms but also to identify potential antifungal targets. This article reviews the current knowledge of the mechanisms of growth and virulence in C. albicans and examines potential targets for the development of new antifungal drugs.

引用

页码：5885 / 5891

页数：7

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