Long-acting muscarinic M3 receptor antagonists -: GlaxoSmithKline

被引：5
|
作者：
Norman, Peter [1 ]
机构：
[1] Norman Consulting, Burnham SL1 8JW, Bucks, England
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2006年 / 16卷 / 09期
关键词：
bronchodilator; COPD; M-3; receptor; muscarinic antagonist; urinary incontinence;
D O I：
10.1517/13543776.16.9.1315
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two applications claim a novel class of muscarinic M-3 receptor antagonists and their use as long-acting agents for the treatment of chronic obstructive pulmonary disease. The two applications claim closely related structures with one claiming quaternary amine salts of the tertiary amines claimed in the other. The claimed compounds comprise a biarylmethylamine core with the amino group modified by acylation or sulfonation and a tertiary or quaternary amine coupled to the distal ring of the biaryl system.
引用
收藏
页码：1315 / 1320
页数：6
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