The influence of sex on microvascular function

被引:1
|
作者
Orphal, Doerte
Gori, Tommaso [1 ]
机构
[1] Univ Med Mainz, Zentrum Kardiol, Kardiol 1, Langenbeckstr 1, D-5131 Mainz, Germany
关键词
Microvascular function; coronary; sex; CARDIAC SYNDROME-X; FRACTIONAL FLOW RESERVE; NORMAL CORONARY ARTERIOGRAMS; CHEST-PAIN; PATHOPHYSIOLOGY; MANAGEMENT; ANGINA; DYSFUNCTION; DIAGNOSIS; ARTERIES;
D O I
10.3233/CH-168103
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A number of studies consistently report higher rates of all clinical outcomes including postinfarction mortality, need for repeat revascularization, and reinfarction inwomen with cardiovascular diseases than in men. As well, the gender gap in the prevalence of cardiovascular diseases decreases progressively with increasing age. Yet, the diagnosis and treatment of these diseases differ between genders and women remain underdiagnosed for coronary heart disease. In a recent retrospective analysis we showed that, along with vessel under study and age, gender is a determinant of adenosine responses during studies of fractional flow reserve, an effect that was probably due to differences in microvascular function and that influenced the interpretation of fractional flow reserve data. These data demonstrate that not only the clinical presentation is different, but also the diagnostic approach to coronary artery disease might differ between sexes. A gap still exists in the understanding of the mechanisms, awareness, and treatment of coronary artery disease in women, but also, as we show, in the application of diagnostic modalities that are well established in men.
引用
收藏
页码:267 / 271
页数:5
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