Epidemiology of Hemoglobinopathies and Thalassemias in Individuals Referred to the Haematology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran From 2006 to 2011

被引：2

作者：

Haghpanah, Sezaneh ^{[1
]}

Ramzi, Mani ^{[1
]}

Zakerinia, Maryam ^{[1
]}

Khojasteh, Habib Nourani ^{[1
]}

Haghshenas, Mansour ^{[1
]}

Rezaei, Narges ^{[1
]}

Moayed, Vida ^{[1
]}

Rezaei, Alireza ^{[1
]}

Karimi, Mehran ^{[1
]}

机构：

[1] Shiraz Univ Med Sci, Haematol Res Ctr, Shiraz, Iran

来源：

HEMOGLOBIN | 2014年 / 38卷 / 04期

关键词：

Epidemiology; hemoglobinopathies; thalassemias; BETA-THALASSEMIA; DISORDERS;

D O I：

10.3109/03630269.2014.921791

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hemoglobinopathies and thalassemias are the most frequent genetic hereditary disorders with an increasing global health burden, especially in low-and middle-income countries. We aimed to determine the epidemiologic pattern of hemoglobinopathies and thalassemias in individuals referred to the Haematology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran, which is the most important referral center in Southern Iran during 2006 to 2011. The most frequent abnormality was beta-thalassemia (beta-thal) minor (24.0%), followed by alpha-thalassemia (alpha-thal) trait (10.0%), hemoglobin (Hb) S trait (4.0%) and Hb D-Punjab trait (4.0%). Because this center is a referral center, we detected a higher prevalence compared to the normal population; however, these data could help policymakers and health service providers to better programming for prevention of births affected with Hb disorders.

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页码：287 / 288

页数：2