Alterations of physostigmine-induced yawning by chronic lithium administration in rats

被引：3
|
作者：
Sharifzadeh, M [1 ]
Abdollahi, M [1 ]
Dehpour, AR [1 ]
Kebriaeezadeh, A [1 ]
Samini, M [1 ]
Mohammad, M [1 ]
机构：
[1] UNIV TEHRAN MED SCI, SCH MED, DEPT PHARMACOL, TEHRAN, IRAN
来源：
PHARMACOLOGY & TOXICOLOGY | 1997年 / 81卷 / 04期
关键词：
D O I：
10.1111/j.1600-0773.1997.tb02062.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of chronic lithium pretreatment on physostigmine-induced yawning was investigated in male rats. Intraperitoneal administration of physostigmine to rats induced yawning in a biphasic manner. However the maximum response was obtained by 0.2 mg/kg of the drug. Intracerebroventricular administrations of a putative M-1 and M-2 muscarinic receptor antagonists, pirenzepine and methoctramine decreased physostigmine-induced yawning. Intraperitoneal administration of a non-selective muscarinic receptor antagonist, atropine, also decreased the physostigmine-induced yawning significantly Chronic lithium pretreatment (30 days) reduced yawning induced by physostigmine. The inhibitory effect of pirenzepine, methoctramine and atropine on physostigmine-induced yawning increased in rats pretreated with chronic lithium. These findings indicate that yawning is induced by a central cholinergic mechanism and that chronic pretreatment of lithium may interact with the cholinergic-induced behaviour.
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页码：159 / 163
页数：5
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