Rabbit allergens: A significant risk for allergic sensitization in subjects without occupational exposure

被引：15
|
作者：
Liccardi, G.
Piccolo, A.
Dente, B.
Salzillo, A.
Noschese, P.
Gilder, J. A.
Russo, M.
D'Amato, G.
机构：
[1] High Special A Cardarelli Hosp, Div Pneumol & Allergol, Dept Chest Dis, I-80122 Naples, Italy
[2] San Paolo Hosp, Lab Clin Pathol, Naples, Italy
[3] Sci Commun, Naples, Italy
来源：
RESPIRATORY MEDICINE | 2007年 / 101卷 / 02期
关键词：
bronchial asthma; pets; rabbit; respiratory allergy; rhinitis;
D O I：
10.1016/j.rmed.2005.11.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Although rabbits are becoming popular as pets, data about the characteristics of allergic sensitization to rabbit allergens in patients without professional exposure are scarce. Aims of the study: To determine the characteristics of allergic sensitization to pet rabbits, and the rote of direct and indirect exposure to rabbits and rabbit allergens in non-professionally exposed patients. Methods: From among 1124 consecutive outpatients, we selected all subjects with an immediate skin reaction to rabbit dander. A clinical history including a careful evaluation of the modality of rabbit exposure, the results of skin-prick tests (SPTs) and totat/specific IgE antibodies were recorded. The prevalence of rabbit ownership in the Naples area was also calculated. Results: Among 753 SPT-positive patients, 20 (2.65%) were sensitized to rabbit dander (5 patients were mono-sensitized). Fifteen patients reported direct rabbit contact (7 were rabbit owners and 8 had occasional contact outside the home); 3 patients had indirect exposure through contact with rabbit owners and 2 patients denied any direct or indirect exposure. Rabbit mono-sensitized owners of pet rabbits had persistent (moderate-severe) symptoms. The prevalence of rabbit ownership is 1.56%. Conclusions: In susceptible not professionally exposed individuals, direct rabbit contact and, in some cases, indirect or no apparent exposure, may induce allergic sensitization to rabbit allergens. A progressive increase in rabbit sensitization (also by indirect exposure) may be expected as a consequence of the increase in rabbit ownership. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：333 / 339
页数：7
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