Differential-pulse polarography determination of pipamperone in pharmaceutical formulations

The electrochemical reduction of pipamperone has been carried out in aqueous solution in KNO3 (0.1 mol l(-1)) by differential-pulse polarography (DPP). Pipamperone exhibits a well-defined irreversible reduction peak at - 1.3 V/ref. The influence of pH on the reduction of pipamperone was studied in Britton-Robinson buffer (pH range 2-10). A method for the analysis of pipamperone in KNO3 (0.1 mol l(-1)), which allows quantification over the range 1.6 x 10(-5)-2.0 x 10(-4) mol l(-1), was proposed and successfully applied to the determination of pipamperone in tablets with mean recovery and relative standard deviation (R.S.D.) of 100.35 and 0.49%, respectively. (C) 2002 Elsevier Science B.V. All rights reserved.