Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis

被引：12
|
作者：
Cao, Ming-xin [1 ,2 ]
Tang, Ya-ling [3 ,4 ]
Zhang, Wei-long [3 ,4 ]
Tang, Ya-Jie [5 ,6 ]
Liang, Xin-hua [1 ,2 ]
机构：
[1] Sichuan Univ, State Key Lab Oral Dis, Dept Oral & Maxillofacial Surg, West China Hosp Stomatol, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, Natl Clin Res Ctr Oral Dis, Dept Oral & Maxillofacial Surg, West China Hosp Stomatol, Chengdu, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Dept Oral Pathol, Chengdu, Sichuan, Peoples R China
[4] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Dept Oral Pathol, Chengdu, Sichuan, Peoples R China
[5] Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China
[6] Hubei Univ Technol, Hubei Prov Cooperat Innovat Ctr Ind Fermentat, Hubei Key Lab Ind Microbiol, Key Lab Fermentat Engn,Minist Educ, Wuhan, Hubei, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2019年 / 9卷
基金：
中国国家自然科学基金;
关键词：
non-coding RNA (ncRNA); lymphangiogenesis; lymphatic development; inflammation; cancer metastasis; GROWTH-FACTOR-C; VASCULAR DEVELOPMENT; VEGF-C; DEPENDENT LYMPHANGIOGENESIS; EMBRYONIC LYMPHANGIOGENESIS; MOLECULAR-MECHANISMS; NEGATIVE REGULATOR; CELLS CONTRIBUTE; PROX1; EXPRESSION; NODE METASTASIS;
D O I：
10.3389/fonc.2019.00916
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving from preexisting vessels, becomes established during embryogenesis, and has a close relationship with pathological conditions such as lymphatic developmental diseases, inflammation, and cancer. This review summarizes the molecular mechanisms of lymphangiogenesis in lymphatic development, inflammation and cancer metastasis, and discusses ncRNAs' regulatory effects on them. Therapeutic targets with regard to lymphangiogenesis are also discussed.
引用
收藏
页数：11
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