A novel four-component synthesis of N-substituted amino acid esters

被引：0

作者：

Henkel, B ^{[1
]}

Weber, L ^{[1
]}

机构：

[1] Morphochem AG, D-81379 Munich, Germany

来源：

SYNLETT | 2002年 / 11期

关键词：

multi-component reaction; amino acids; polymer-supported synthesis; combinatorial chemistry; Lewis acids;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of N-substituted amino acid esters was synthesized using a solid phase bound organic isocyanide that provides a C1 synthon to the final molecule. This novel four-component, one-pot reaction delivers the final products in acceptable yields with high purities of the crude reaction products, facilitating the final purification. The preparation of the isocyano resin is also described the intermediates being controlled by ATR-spectroscopy.

引用

页码：1877 / 1879

页数：3

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