A novel four-component synthesis of N-substituted amino acid esters

被引：0

作者：

Henkel, B ^{[1
]}

Weber, L ^{[1
]}

机构：

[1] Morphochem AG, D-81379 Munich, Germany

来源：

SYNLETT | 2002年 / 11期

关键词：

multi-component reaction; amino acids; polymer-supported synthesis; combinatorial chemistry; Lewis acids;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of N-substituted amino acid esters was synthesized using a solid phase bound organic isocyanide that provides a C1 synthon to the final molecule. This novel four-component, one-pot reaction delivers the final products in acceptable yields with high purities of the crude reaction products, facilitating the final purification. The preparation of the isocyano resin is also described the intermediates being controlled by ATR-spectroscopy.

引用

页码：1877 / 1879

页数：3

共 50 条

[1] Tandem four-component reaction for efficient synthesis of dihydrothiophene with substituted amino acid ethyl esters
Sun, Jing
Zhang, Yu
Yan, Chao-Guo
[J]. RSC ADVANCES, 2018, 8 (40): : 22498 - 22505
[2] A One-Pot, Four-Component Synthesis of N-Substituted 2,4-Diarylimidazoles
Adib, Mehdi
Ansari, Samira
Feizi, Shahzad
Damavandi, Jafar Asgarian
Mirzaei, Peiman
[J]. SYNLETT, 2009, (20) : 3263 - 3266
[3] Choline esters of N-substituted amino acids. IX. Synthesis and cholinergic properties of β-dimethylaminoethyl esters of N-substituted amino acids
Topuzyan V.O.
Khachvakyan G.Y.
Shakhbazyan L.V.
Gerasimyan D.A.
[J]. Pharmaceutical Chemistry Journal, 1997, 31 (1) : 23 - 26
[4] A NOVEL SYNTHESIS OF N-SUBSTITUTED AMINO-ACIDS
NAIM, SS
KHAN, NH
SIDDIQUI, AA
[J]. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1980, 19 (07): : 622 - 624
[5] ASYMMETRIC-SYNTHESIS OF N-SUBSTITUTED ALPHA-AMINO ESTERS
LORETO, MA
PELLACANI, L
TARDELLA, PA
[J]. TETRAHEDRON LETTERS, 1989, 30 (22) : 2975 - 2978
[6] Four-Component Approach to N-Substituted Phenothiazines under Transition-Metal-Free Conditions
Chen, Jinjin
Li, Guozheng
Xie, Yanjun
Liao, Yunfeng
Xiao, Fuhong
Deng, Guo-Jun
[J]. ORGANIC LETTERS, 2015, 17 (23) : 5870 - 5873
[7] A versatile synthesis of α-amino acid derivatives via the Ugi four-component condensation with a novel convertible isonitrile
Rikimaru, Kentaro
Yanagisawa, Arata
Kan, Toshiyuki
Fukuyama, Tohru
[J]. HETEROCYCLES, 2007, 73 (01) : 403 - +
[8] SYNTHESIS OF N-SUBSTITUTED AMINO ACID-P-NITROBENZYL-ESTERS AS POTENTIAL ACE-INHIBITORS
BOTTCHER, M
HENKLEIN, P
HOFFMANN, K
HEDER, G
SIEMS, WE
NIEDRICH, H
[J]. PHARMAZIE, 1986, 41 (02): : 140 - 140
[9] A NOVEL SYNTHESIS OF N-SUBSTITUTED ALPHA-AMINO KETONES
LOCIURO, S
PELLACANI, L
TARDELLA, PA
[J]. TETRAHEDRON LETTERS, 1983, 24 (06) : 593 - 596
[10] A versatile synthesis of α-amino acid derivatives via the ugi four-component condensation with a novel convertible isonitrile
Rikimaru, K
Yanagisawa, A
Kan, T
Fukuyama, T
[J]. SYNLETT, 2004, (01) : 41 - 44

← 1 2 3 4 5 →