AN EFFICIENT AND NOVEL PROCESS FOR THE SYNTHESIS OF NIZATIDINE

被引：0

作者：

Srinivasarao, Talasila ^{[1
]}

Mohanty, Sandeep ^{[1
]}

Suryanarayana, Venkata Ch ^{[1
]}

Reddy, G. Sandeep ^{[1
]}

Jaydeepkumar ^{[2
]}

Rao, B. Venkateswara ^{[3
]}

机构：

[1] Dr Reddys Labs Ltd, Proc Res & Dev, API Plant, Plot Nos 116,126C,Survey 157, Ida Bollaram 502325, Telangana, India

[2] Dr Reddys Labs Ltd, Ctr Excellence Integrated Prod Dev, Innovat Plaza, Qutubullapur 500072, Andhra Pradesh, India

[3] Andhra Univ, Dept Engn Chem, Visakhapatnam 500003, Andhra Pradesh, India

来源：

HETEROCYCLIC LETTERS | 2019年 / 9卷 / 02期

关键词：

Ethyl bromopyruvate; 2-(dimethylamino) ethanethioamide; K2CO3; Cysteamine hydrochloride; NaBH4 andN-methyl-1-(methylthio)-2-nitroethenamine; THIAZOLES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile echo friendly, cost effective and robust process for the synthesis of Nizatidine via the cyclocondensation of 2-(dimethylamino) ethanethioamide with ethyl bromopyruvate followed by reduction then coupled with cysteamine hydrochloride. The later formed product was coupled with (N-methyl-1-(methylthio)-2-nitroethenamine in water resulted Nizatidine. The synthesized product was meet European pharmacopeia (EP) monograph.

引用

页码：191 / 195

页数：5

共 50 条

[21] A Simple and Efficient Process for the Synthesis of Novel Heterocycles Containing Benzofuran Moiety Using Thiocarbohydrazide as a Precursor
Baashen, Mohammed A.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (07) : 1953 - 1957
[22] A concise and efficient novel synthesis of cleviolide
Rossi, R
Bellina, F
Biagetti, M
SYNTHETIC COMMUNICATIONS, 1999, 29 (19) : 3415 - 3420
[23] Novel and efficient synthesis of perfluoroalkylated arylphosphines
Chen, WP
Xiao, JL
TETRAHEDRON LETTERS, 2000, 41 (19) : 3697 - 3700
[24] A concise and efficient novel synthesis of cleviolide
Dipto. Chim. e Chim. Industriale, Università di Pisa, Via Risorgimento 35, I-56126 Pisa, Italy
Synth. Commun., 19 (3415-3420):
[25] Novel and Efficient Synthesis of Pyrimidine Derivatives
Ghagare, Maruti G.
Birari, Dilip R.
Shelar, Deepak P.
Toche, Raghunath B.
Jachak, Madhukar N.
SYNTHETIC COMMUNICATIONS, 2010, 40 (11) : 1580 - 1587
[26] A novel and efficient total synthesis of shikonin
Wang, Rubing
Guo, Hui
Cui, Jiahua
Li, Shaoshun
TETRAHEDRON LETTERS, 2012, 53 (31) : 3977 - 3980
[27] Novel and Efficient Synthesis of Unsymmetrical Trisulfides
Lach, Slawomir
Sliwka-Kaszynska, Magdalena
Witt, Dariusz
SYNLETT, 2010, (19) : 2857 - 2860
[28] EFFICIENT APPROACH TO SYNTHESIS OF NOVEL HETEROCYCLES
Shin, Dongsoo
PROGRESS ON POST-GENOME TECHNOLOGIES AND MODERN NATURAL PRODUCTS, 2011, 2011, : 56 - 57
[29] A novel and efficient total synthesis of cephalotaxine
Li, WDZ
Wang, YQ
ORGANIC LETTERS, 2003, 5 (16) : 2931 - 2934
[30] A novel and efficient route for synthesis of Taladegib
Guo, Mingliang
Hong, Kwon Ho
Lv, Yongfeng
Ding, Yu
Li, Congcong
Xu, Hua
Qi, Wenxiu
Chen, Junqing
Ji, Min
Cai, Jin
JOURNAL OF CHEMICAL RESEARCH, 2017, (02) : 112 - 115

← 1 2 3 4 5 →