Effect of Octreotide on Colonic Motility in Pediatric Patients With Chronic Recalcitrant Constipation

Objective:The aim of the present study was to study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders.Methods:This was a nonrandomized, single-center, open-label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility.Results:Thirteen patients (5 boys) were enrolled in the study. The age range was 4.6 to 16.2 years. Eleven patients (84%) had normal colonic manometry and 2 patients (16%) had colonic neuropathy. Motility Index (MI) (mmHg) for the 15 minutes before and after octreotide infusion was 6.031.26 (95% confidence interval [CI] 5.35-6.72) and 5.32 +/- 1.66 (95% CI 4.42-6.23), respectively, with P value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89 +/- 1.37 (95% CI 6.14-7.64) and 6.71 +/- 1.47 (95% CI 5.91-7.52), respectively, with P value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73 +/- 1.32 (95% CI 7.01-8.45) and 7.53 +/- 1.38 (95% CI 6.78-8.28), respectively, with P value of 0.8.Conclusion:Our study showed that the administration of octreotide resulted in no significant changes in colonic MI in pediatric patients with chronic recalcitrant constipation.