Comparison of amitriptyline metabolism in hepatocytes from streptozocin-induced diabetic rats and from non-diabetic rats

被引：2

作者：

Coudore, F ^{[1
]}

Besson, A ^{[1
]}

Shrivastava, R ^{[1
]}

Chevalier, A ^{[1
]}

Eschalier, A ^{[1
]}

Lavarenne, J ^{[1
]}

Massingham, R ^{[1
]}

Fialip, J ^{[1
]}

机构：

[1] CERM,RIOM LABS,CTR RECH & DEV,RIOM,FRANCE

来源：

CELL BIOLOGY AND TOXICOLOGY | 1997年 / 13卷 / 02期

关键词：

diabetes; rat; cell culture; antidepressant; kinetics; biotransformation;

D O I：

10.1023/B:CBTO.0000010398.63757.4c

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Biotransformation of amitriptyline (AMI) was studied at different intervals in freshly isolated hepatocytes from healthy or streptozocin-induced diabetic rats in order to investigate the influence of the diabetic state. Levels of free and conjugated AMI, demethylated and hydroxylated metabolites, were assessed by HPLC analysis. In hepatocytes isolated from diabetic rats, AMI was less completely metabolized and the demethylation reaction became more important than in nondiabetic rat hepatocytes. Although the proportions of hydroxylated metabolites decreased in diabetic rats, it always remained predominant. Furthermore, glucuronidation of metabolites was greater, especially for (Z)-10-hydroxynortriptyline in diabetic animals.

引用

页码：131 / 137

页数：7

共 50 条

[31] ALTERATIONS IN RETROGRADE AXONAL-TRANSPORT IN STREPTOZOCIN-INDUCED DIABETIC RATS
FINK, DJ
PURKISS, D
MATA, M
[J]. DIABETES, 1987, 36 (09) : 996 - 1000
[32] Aminoguanidine prevents bone structure changes in Streptozocin-induced diabetic rats
Yavuz, Dilek Gogas
Parmaksiz, Ilker
Cetinel, Sule
Ahiskali, Rengin
Ersoy, Yasemin
Tugtepe, Halil
Yazici, Dilek
Sirikci, Cinder
Akalin, Sema
[J]. DIABETES, 2008, 57 : A310 - A310
[33] Effect of Biochanin A on Serum Visfatin Level of Streptozocin-Induced Diabetic Rats
Azizi, Reza
Goodarzi, Mohamad Taghi
Salemi, Zahra
[J]. IRANIAN RED CRESCENT MEDICAL JOURNAL, 2014, 16 (09)
[34] Effect of Ramipril Alone Compared to Ramipril with Eplerenone on Diabetic Nephropathy in Streptozocin-Induced Diabetic Rats
Mavrakanas, Thomas A.
Cheva, Angeliki
Kallaras, Konstantinos
Karkavelas, Georgios
Mironidou-Tzouveleki, Maria
[J]. PHARMACOLOGY, 2010, 86 (02) : 85 - 91
[35] Metabolism of troglitazone in hepatocytes isolated from experimentally induced diabetic rats
Meechan, A. J.
Henderson, C.
Bates, C. D.
Grant, M. H.
Tettey, J. N. A.
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2006, 58 (10) : 1359 - 1365
[36] Heroin acts on delta opioid receptors in the brain of streptozocin-induced diabetic rats
Holmes, BB
Rady, JJ
Fujimoto, JM
[J]. PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1998, 218 (04): : 334 - 340
[37] Early effects of hyperglycemia on retinal taurine uptake of streptozocin-induced diabetic rats
Balzano, L
Lepore, D
DiLeo, MAS
Portale, G
Antico, L
Molle, F
Caputo, S
Ghirlanda, G
Scullica, L
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1996, 37 (03) : 4486 - 4486
[38] The Safety and Efficacy of Combining Saxagliptin and Pioglitazone Therapy in Streptozocin-Induced Diabetic Rats
Othman, Ahmed Mohamed
Ibrahim, Ibrahim Ashour
Saleh, Samy M.
Abo-Elmatty, Dina M.
Mesbah, Noha M.
Abdel-Hamed, Asmaa R.
[J]. BIOMEDICINES, 2023, 11 (12)
[39] DISTRIBUTION OF ELEMENTS AND WATER IN PERIPHERAL-NERVE OF STREPTOZOCIN-INDUCED DIABETIC RATS
LOWERY, JM
EICHBERG, J
SAUBERMANN, AJ
LOPACHIN, RM
[J]. DIABETES, 1990, 39 (12) : 1498 - 1503
[40] Ketogenic diet modulates cardiac metabolic dysregulation in streptozocin-induced diabetic rats
Trang, Nguyen Ngoc
Lee, Ting-Wei
Kao, Yu-Hsun
Chao, Tze-Fan
Lee, Ting-, I
Chen, Yi-Jen
[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023, 111

← 1 2 3 4 5 →