Synthesis and structural elucidation of a new zooecdysteroid gerardiasterone

被引：13
|
作者：
Tsubuki, M [1 ]
Takada, H [1 ]
Katoh, T [1 ]
Miki, S [1 ]
Honda, T [1 ]
机构：
[1] HOSHI UNIV,INST MED CHEM,SHINAGAWA KU,TOKYO 142,JAPAN
来源：
TETRAHEDRON | 1996年 / 52卷 / 46期
关键词：
D O I：
10.1016/0040-4020(96)00897-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first synthesis of a new zooecdysteroid gerardiasterone was achieved in a diastereoselective manner employing asymmetric dihydroxylation of the E-olefin 34 in the presence of DHQ-CLB as a chiral ligand. This synthesis unambiguously confirmed the structure of gerardiasterone as (20R,22R,23S)-2 beta,3 beta,14 alpha,20,22,23,25-heptahydroxy-5 beta-cholest-7-en-6-one (2a). Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：14515 / 14532
页数：18
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