Estimating the product-moment correlation in samples with censoring on both variables

被引:0
|
作者
Piepho, HP
Thöni, H
Müller, HM
机构
[1] Univ Hohenheim, Inst Pflanzenbau & Grunland, Fachgebiet Bioinformat, D-70599 Stuttgart, Germany
[2] Univ Hohenheim, Inst Angew Math & Stat, D-70593 Stuttgart, Germany
[3] Univ Hohenheim, Inst Tierernahrung, D-70593 Stuttgart, Germany
关键词
bivariate normal distribution; censoring; informative drop-out mechanism; informative missingness; maximum likelihood (ML);
D O I
10.1002/1521-4036(200209)44:6<657::AID-BIMJ657>3.0.CO;2-Z
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Bivariate samples may be subject to censoring of both random variables. For example, for two toxins measured in batches of wheat grain, there may be specific detection limits. Alternatively, censoring may be incomplete over a certain domain, with the probability of detection depending on the toxin level. hi either case, data are not missing at random, and the missing data pattern bears some information on the parameters of the underlying model (informative missingness), which can be exploited for a fully efficient analysis. Estimation (after suitable data transformation) of the correlation in such samples is the subject of the present paper. We consider several estimators. The first is based on the tetrachoric correlation. It is simple to compute, but does not exploit the full information. The other two estimators exploit all information and use full maximum likelihood, but involve heavier computations. The one assumes fixed detection limits, while the other involves a logistic model for the probability of detection. For a real data set, a logistic model for the probability of detection fitted markedly better than a model with fixed detection limits, suggesting that censoring is not complete.
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页码:657 / 670
页数:14
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