Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators

被引：29

作者：

Zhang, Xuqing ^{[1
]}

Allan, George F. ^{[1
]}

Sbriscia, Tifanie ^{[1
]}

Linton, Olivia ^{[1
]}

Lundeen, Scott G. ^{[1
]}

Sui, Zhihua ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Drug Discovery, Exton, PA 19341 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 22期

关键词：

SARMs; hydantoin;

D O I：

10.1016/j.bmcl.2006.08.084

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of hydantoin derivatives were identified by in vivo studies as tissue selective androgen receptor modulators. SAR around this series revealed that the function of the ligand could be altered by minor structural modification. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5763 / 5766

页数：4

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