Novel androgen therapies including selective androgen receptor modulators

被引：5
|
作者：
Kang, Jungwoo [1 ]
Chen, Runzhi [2 ]
Tharakan, Tharu [1 ]
Minhas, Suks [3 ]
机构：
[1] London Northwest Univ Healthcare NHS Trust, Northwick Pk Hosp, Dept Urol, Harrow HA1 3UJ, England
[2] Imperial Coll London, Fac Med, Sir Alexander Fleming Bldg,Imperial Coll Rd, London SW7 2AZ, England
[3] Imperial Coll Healthcare NHS Trust, Charing Cross Hosp, Dept Urol, London W6 8RF, England
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2022年 / 36卷 / 05期
关键词：
male hypogonadism; testosterone replacement therapy; novel androgen therapies; nasal testosterone; TESTOSTERONE REPLACEMENT THERAPY; CONTRACEPTIVE EFFICACY; INFLAMMATORY CYTOKINES; AROMATASE INHIBITION; CLOMIPHENE CITRATE; HYPOGONADAL MEN; DOUBLE-BLIND; ELDERLY-MEN; RISK-FACTOR; OLDER MEN;
D O I：
10.1016/j.beem.2022.101686
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Male hypogonadism is associated with reduced quality of life and the development of co-morbidities including obesity, diabetes mellitus, and dyslipidaemia. The mainstay of treatment for male hypogonadism is testosterone replacement therapy (TRT). How-ever, TRT has recognised side effects including impaired sper-matogenesis and there are concerns regarding its use in men with concurrent cardiovascular disease. Thus, there has been an impetus to develop novel androgen therapies for treating male hypogonadism to mitigate the side effects of TRT. This review will discuss the benefits and adverse effects of TRT, and novel therapies including nasal testosterone, aromatase inhibitors, selective oes-trogen receptor modulators, and selective androgen receptor modulators.(c) 2022 Elsevier Ltd. All rights reserved.
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页数：17
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