Effect of pulmonary exacerbations treated with oral antibiotics on clinical outcomes in cystic fibrosis
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作者:
Stanojevic, Sanja
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Univ Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, CanadaUniv Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, Canada
Stanojevic, Sanja
[1
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McDonald, Alexandra
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Univ Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, CanadaUniv Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, Canada
McDonald, Alexandra
[1
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Waters, Valerie
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机构:
Univ Toronto, Hosp Sick Children, Div Infect Dis, Dept Pediat, Toronto, ON, CanadaUniv Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, Canada
Waters, Valerie
[2
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MacDonald, Sarah
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机构:
Univ Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, CanadaUniv Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, Canada
MacDonald, Sarah
[1
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Horton, Eric
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机构:
Univ Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, CanadaUniv Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, Canada
Horton, Eric
[1
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Tullis, Elizabeth
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机构:
Li Ka Shing Knowledge Inst, Div Respirol, Keenan Res Ctr, Toronto, ON, Canada
Univ Toronto, St Michaels Hosp, Dept Med, Toronto, ON, CanadaUniv Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, Canada
Tullis, Elizabeth
[3
,4
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Ratjen, Felix
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Univ Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, CanadaUniv Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, Canada
Ratjen, Felix
[1
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机构:
[1] Univ Toronto, Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON, Canada
[2] Univ Toronto, Hosp Sick Children, Div Infect Dis, Dept Pediat, Toronto, ON, Canada
[3] Li Ka Shing Knowledge Inst, Div Respirol, Keenan Res Ctr, Toronto, ON, Canada
[4] Univ Toronto, St Michaels Hosp, Dept Med, Toronto, ON, Canada
Background Despite extensive knowledge regarding the effect of pulmonary exacerbations treated with intravenous antibiotics on clinical outcomes in cystic fibrosis (CF), there is little known about the role of milder pulmonary exacerbations treated with oral antibiotics (oPEx). Methods This was a retrospective cohort study of patients with CF followed at the Hospital for Sick Children and St. Michael's Hospital from 2009 to 2014. We evaluated the effect of oPEx on short-term clinical outcomes as the proportion of oPEx events in which 100% or 90% of baseline FEV1% predicted was recovered at the end of treatment. We then examined the association of the number of oPEx events in the past 12 months on lung function (FEV1% predicted) and nutritional status (body mass index (BMI) z-score) using a mixed-effects model. Results There were a total of 2608 oPEx events in 570 subjects during the study period. In over half (53.4%) of oPEx events, lung function was already at 90% or higher of baseline FEV1 at the initiation of oral antibiotic therapy and 82% were at 90% or higher of baseline FEV1 at follow-up. In individuals with CF, one or more oPex events in the previous 12 months were associated with decreased FEV1 compared with 12 months periods without oPex events. When the cumulative effect of oPExs on lung function was examined over the entire study period, patients with six or more oPEx events had the steepest rate of FEV1 decline. oPEx events were not associated with changes in BMI. Conclusions oPEx events are associated with short-term loss of FEV1 and have a negative effect on lung function over time.
机构:
Childrens Hosp Colorado, Dept Pediat, Aurora, CO USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
Sagel, Scott D.
Thompson, Valeria
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机构:
Univ Colorado, Sch Med, Aurora, CO USA
Seattle Childrens Res Inst, Cyst Fibrosis Fdn, Therapeut Dev Network Coordinating Ctr, Seattle, WA USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
Thompson, Valeria
Chmiel, James F.
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机构:
Case Western Reserve Univ, Dept Pediat, Sch Med, Cleveland, OH 44106 USA
Rainbow Babies & Childrens Hosp, Cleveland, OH 44106 USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
Chmiel, James F.
Montgomery, Gregory S.
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机构:
Riley Hosp Children, Dept Pediat, Indianapolis, IN USA
Indiana Univ Sch Med, Indianapolis, IN 46202 USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
Montgomery, Gregory S.
Nasr, Samya Z.
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机构:
Univ Michigan Hlth Syst, Dept Pediat, Ann Arbor, MI USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
Nasr, Samya Z.
Perkett, Elizabeth
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机构:
Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
Perkett, Elizabeth
Saavedra, Milene T.
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机构:
Natl Jewish Hlth, Dept Med, Denver, CO USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
Saavedra, Milene T.
Slovis, Bonnie
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机构:
Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
Slovis, Bonnie
Anthony, Margaret M.
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机构:
Childrens Hosp Colorado, Dept Pediat, Aurora, CO USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
Anthony, Margaret M.
Emmett, Peggy
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机构:
Univ Colorado Denver, Pediat Clin Translat Res Ctr, Core Lab, Childrens Hosp Colorado, Aurora, CO USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
Emmett, Peggy
Heltshe, Sonya L.
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机构:
Univ Washington, Dept Pediat, Sch Med, Seattle, WA 98195 USA
Seattle Childrens Res Inst, Cyst Fibrosis Fdn, Therapeut Dev Network Coordinating Ctr, Seattle, WA USAChildrens Hosp Colorado, Dept Pediat, Aurora, CO USA
机构:
Univ Nottingham, Div Child Hlth, Queens Med Ctr, Nottingham NG7 2UH, EnglandUniv Nottingham, Div Child Hlth, Queens Med Ctr, Nottingham NG7 2UH, England