Umbilical cord blood transplantation: Where do we stand?

被引：18
|
作者：
Wadlow, RC
Porter, DL
机构：
[1] Univ Penn, Med Ctr, Div Hematol Oncol, Bone Marrow & Stem Cell Transplant Program, Philadelphia, PA 19104 USA
[2] Univ Penn, Med Ctr, Dept Med, Philadelphia, PA 19104 USA
来源：
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2002年 / 8卷 / 12期
关键词：
allogeneic stem cell transplantation; graft-versus-host disease; HLA matching; umbilical cord blood;
D O I：
10.1053/bbmt.2002.v8.abbmt080637
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although allogeneic stem cell transplantation can cure patients with hematologic malignancies, limiting factors such as lack of suitable donors and GVHD toxicity have led to the exploration. of umbilical cord blood (UCB) as an alternative source of hematopoietic stem cells. This overview examines the advantages and disadvantages of UCB as a donor source and reviews data from preclinical and clinical studies. Ethical issues regarding UCB transplantation are also addressed.
引用
收藏
页码：637 / 647
页数：11
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