Mutations of PIP2 sensitive sites have a strong impact on the sensitivity of Kir2.1 and Kir2.3 channels to cholesterol.

被引:0
|
作者
Epshtein, Yulia [1 ]
Morris, Scott [1 ]
Levitan, Irena [1 ]
机构
[1] UIC, Chicago, IL USA
关键词
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:28A / 28A
页数:1
相关论文
共 34 条
  • [21] Endothelial PIP2 Bidirectionally Modulates TRPV4 and Kir2.1 Signaling in the Brain Capillary Endothelium
    Harraz, Osama F.
    Nelson, Mark T.
    JOURNAL OF GENERAL PHYSIOLOGY, 2016, 148 (02): : 15A - 15A
  • [22] Regulation of single channel gating in the strong inward rectifier potassium channel (Kir2.1) by phosphatidylinositoir-4,5-bisphosphate (PIP2)
    Xie, Lai-Hua
    John, Scott A.
    Ribalet, Bernard
    Weiss, James N.
    BIOPHYSICAL JOURNAL, 2007, : 108A - 108A
  • [23] Hypoxia inhibits the cardiac Ik1 current through SUMO targeting Kir2.1 activation by PIP2
    Xu, Yu
    Yang, Yuchen
    Chandrashekar, Aishwarya
    Gada, Kirin D.
    Masotti, Meghan
    Baggetta, Austin M.
    Connolly, Jenna G.
    Kawano, Takeharu
    Plant, Leigh D.
    ISCIENCE, 2022, 25 (09)
  • [24] PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity
    Dabertrand, Fabrice
    Harraz, Osama F.
    Koide, Masayo
    Longden, Thomas A.
    Rosehart, Amanda C.
    Hill-Eubanks, David C.
    Joutel, Anne
    Nelson, Mark T.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (17)
  • [25] Cross-Talk between Cholesterol, PIP2 and Caveolin in Regulating Kir2 Channels
    Han, Huazhi
    Rosenhouse-Dantsker, Avia
    Gnanasambandam, Radhakrishnan
    Sachs, Frederick
    Levitan, Irena
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 608A - 608A
  • [26] E224G Regulation of the PIP2-Induced Gating Kinetics of Kir2.1 Channels
    Ren, Shu-Xi
    Li, Jun-Wei
    Zhang, Su-Hua
    Logothetis, D. E.
    An, Hai-Long
    Zhan, Yong
    CHINESE PHYSICS LETTERS, 2017, 34 (01)
  • [27] E224G Regulation of the PIP2-Induced Gating Kinetics of Kir2.1 Channels
    任树喜
    李军委
    张素花
    D.E.Logothetis
    安海龙
    展永
    Chinese Physics Letters, 2017, 34 (01) : 91 - 94
  • [28] Multiple Ba2+ sites in selectivity filter of inwardly rectifying K+-channels Kir2.1
    Pekhletski, R
    D'Avanzo, N
    Cho, HC
    Backx, P
    BIOPHYSICAL JOURNAL, 2004, 86 (01) : 124A - 124A
  • [29] Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2)
    Ha, Junghoon
    Xu, Yu
    Kawano, Takeharu
    Hendon, Tyler
    Baki, Lia
    Garai, Sumanta
    Papapetropoulos, Andreas
    Thakur, Ganesh A.
    Plant, Leigh D.
    Logothetis, Diomedes E.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (10) : 3546 - 3561
  • [30] Cryo-electron microscopy structure of human Kir2.1 potassium channel bound to the activator PIP2 reveals its gating mechanism
    Fernandes, Carlos A. H.
    Zuniga, Dania
    Veloso, Rafael F.
    Zoumpoulakis, Andreas
    Wagner, Renaud
    Venien-Bryan, Catherine
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 28A - 28A