Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells

被引：20
|
作者：
Paterson, Alison M. [1 ]
Sharpe, Arlene H. [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
来源：
NATURE IMMUNOLOGY | 2010年 / 11卷 / 02期
关键词：
AUTOIMMUNE-DISEASE; TOLERANCE;
D O I：
10.1038/ni0210-109
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CTLA-4 is a potent coinhibitory molecule that is critical for peripheral T cell tolerance. New data suggest that CTLA-4 exerts its critical immunoregulatory functions by controlling antigen-specific conventional T cells as well as regulatory T cells.
引用
收藏
页码：109 / 111
页数：4
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