Adsorption of bilirubin by amine-containing crosslinked chitosan resins

被引：17
|
作者：
Yu, YH [1 ]
He, BL
Gu, HQ
机构：
[1] Tianjin Univ, Dept Biochem Engn, Tianjin 300072, Peoples R China
[2] Nankai Univ, State Key Lab Funct Polymer Mat Adsorpt & Separat, Tianjin 300071, Peoples R China
[3] Tianjin Inst Urol Surg, Tianjin 300040, Peoples R China
来源：
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY | 2000年 / 28卷 / 04期
基金：
中国国家自然科学基金;
关键词：
chitosan; functionalization; adsorption; bilirubin;
D O I：
10.3109/10731190009119361
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Crosslinked chitosan resin, which has good blood compatibility, was prepared by crosslinking chitosan solution with glutaraldehyde. Polymeric adsorbents for bilirubin have been synthesized by chemical modification of crosslinked chitosan resins with di-, tri-, tetra-, and pentammines. The adsorption of bilirubin on the adsorbents was investigated in detail. The results indicated that electrostatic interaction and hydrophobic interactions are the main driving forces for the adsorption. Compared with crosslinked chitosan resin, the functionalized chitosan beads have higher adsorption capacity for unconjugated and conjugated bilirubin.
引用
收藏
页码：307 / 320
页数：14
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