Synthetic studies on spongistatins: synthesis of the C29-C44 fragment

被引：22

作者：

Samadi, M ^{[1
]}

Munoz-Letelier, C ^{[1
]}

Poigny, S ^{[1
]}

Guyot, M ^{[1
]}

机构：

[1] Museum Natl Hist Nat, CNRS, Lab Chim Subst Nat, F-75005 Paris, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(00)00383-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent synthesis of the C29-C44 fragment, the common subunit of the spongipyran macrolides is described. The key step of the synthesis is the C-glycosidation reaction which is based on coupling of the lithiated F-ring sulfone with the E-ring aldehyde, and subsequent reductive desulfonylation to afford the E-F bis (pyran) with high stereoselectivity at the anomeric carbon. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：3349 / 3353

页数：5

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