Lack of effect of habenula lesion on heroin self-administration in rats

被引：13

作者：

Wang, Yuhong ^{[2
,3
,4
]}

Zhang, Fuqiang ^{[1
]}

Tang, Shuaien ^{[1
]}

Lai, Miaojun ^{[1
]}

Hao, Wei ^{[2
,3
]}

Zhang, Yong ^{[4
]}

Yang, Jianli ^{[4
]}

Zhou, Wenhua ^{[1
]}

机构：

[1] Ningbo Univ, Sch Med, Ningbo Addict Res & Treatment Ctr, Lab Behav Neurosci, Ningbo 315010, Zhejiang, Peoples R China

[2] Cent S Univ, Xiangya Affiliated Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China

[3] Cent S Univ, Xiangya Affiliated Hosp 2, WHO Collaborating Ctr Drug Abuse & Hlth, Changsha, Hunan, Peoples R China

[4] Tianjin Anding Hosp, Mental Hlth Inst Tianjin, Tianjin, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2009年 / 461卷 / 02期

基金：

中国国家自然科学基金; 浙江省自然科学基金;

关键词：

Habenula; Heroin; Reward; Self-administration; Motivation; NUCLEUS-ACCUMBENS DOPAMINE; LATERAL HABENULA; STIMULATION; NEURONS; COMPLEX; REWARD; INITIATION; BEHAVIOR; PATHWAY; SYSTEM;

D O I：

10.1016/j.neulet.2009.06.029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the effects of bilateral electric lesion of the habenula (Hb) on the acquisition and maintenance of heroin self-administration. The rats were trained to self-administer heroin (0.05 mg/kg/infusion) under FR1 schedule in daily 4 h sessions. A progressive ratio schedule (PR3-4) was used to evaluate the relative motivational value of heroin reinforcement. Compared with the controls, neither pre-training nor post-training of Hb lesions had any effects on the total amount of infusions and motivational value of heroin reward. However, pre-training Hb lesion caused transient active and inactive nose-poke responding in the early phase of training, suggesting increased locomotor exploration. The results suggest that Hb might not play an important role in mediating the acute reinforcing effect of heroin. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：167 / 171

页数：5

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