Noncoding RNA of Glutamine Synthetase I Modulates Antibiotic Production in Streptomyces coelicolor A3(2)

被引：34
|
作者：
D'Alia, Davide [1 ]
Nieselt, Kay [2 ]
Steigele, Stephan [2 ]
Mueller, Jonas [2 ]
Verburg, Ilse [1 ]
Takano, Eriko [1 ]
机构：
[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Microbial Physiol, NL-9751 NN Haren, Netherlands
[2] Univ Tubingen, Ctr Bioinformat Tubingen, Dept Informat & Cognit Sci, D-72076 Tubingen, Germany
来源：
JOURNAL OF BACTERIOLOGY | 2010年 / 192卷 / 04期
关键词：
HUMAN GENOME; MYCOBACTERIUM-TUBERCULOSIS; STRUCTURED RNAS; VIBRIO-HARVEYI; IDENTIFICATION; GENE; PREDICTION; ENCODES; ABSB;
D O I：
10.1128/JB.01374-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Overexpression of antisense chromosomal cis-encoded noncoding RNAss (ncRNAs) in glutamine synthetase I resulted in a decrease in growth, protein synthesis, and antibiotic production in Streptomyces coelicolor. In addition, we predicted 3,597 cis-encoded ncRNAs and validated 13 of them experimentally, including several ncRNAs that are differentially expressed in bacterial hormone-defective mutants.
引用
收藏
页码：1160 / 1164
页数：5
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