Endothelial progenitor cells in pulmonary hypertension - dawn of cell-based therapy?

被引：11

作者：

Toshner, M. ^{[2
]}

Morrell, N. W. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Med, Sch Clin Med, Addenbrookes Hosp, Cambridge CB2 2QQ, England

[2] Papworth Hosp, Cambridge CB3 8RE, England

来源：

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2010年 / 64卷

关键词：

MARROW-DERIVED CELLS; ARTERIAL-HYPERTENSION; GENE-THERAPY; BLOOD; TRANSPLANTATION; GROWTH; PRECURSORS; CONTRIBUTE; EFFICACY; DISEASE;

D O I：

10.1111/j.1742-1241.2009.02232.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>There is mounting interest in the concept of endothelial progenitor cell (EPC) therapy for the treatment of pulmonary arterial hypertension (PAH). Recent successful pilot studies in idiopathic PAH have raised questions about the contribution of progenitor cells circulating in the peripheral blood to pulmonary vascular homeostasis and to the process of vascular remodelling. This review will summarise the work performed to date in animal and human therapeutic trials and clarify what is known about the potential contribution of EPCs to the pathophysiology of PAH.

引用

页码：7 / 12

页数：6

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