New bromotyrosine alkaloids from the marine sponge Psammaplysilla purpurea

被引：53
|
作者：
Tilvi, S [1 ]
Rodrigues, C [1 ]
Naik, CG [1 ]
Parameswaran, PS [1 ]
Wahidhulla, S [1 ]
机构：
[1] Natl Inst Oceanog, Panaji, Goa, India
来源：
TETRAHEDRON | 2004年 / 60卷 / 45期
关键词：
antimicrobial activity; bromotyrosine alkaloids; marine sponge; Psammaplysilla purpurea; purpurealidin;
D O I：
10.1016/j.tet.2004.09.009
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Seven new bromotyrosine alkaloids Purpurealidin A, B, C, D, F, G, H and the known compounds Purealidin Q, Purpurealidin E, 16-Debromoaplysamine-4 and Purpuramine I have been isolated from the marine sponge Psammaplysilla purpurea. Their structure was elucidated on the basis of detailed 1D, 2D NMR and MS spectroscopic data. Purpurealidin B, 16-Debromoaplysamine-4 and Purpuramine I exhibited in vitro antimicrobial activities against E. coli, S. aureus, and V. cholerae. In addition, Purpurealidin B and 16-Debromoaplysamine-4 were also active against Shigella flexineri and Salmonella typhi while Purealidin Q was bactericidal only against Salmonella typhi. (C) 2004 Elsevier Ltd. All rights reserved.
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页码：10207 / 10215
页数：9
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