Mathematical Modelling of the Impact of Non-Pharmacological Strategies to Control the COVID-19 Epidemic in Portugal

被引:9
|
作者
Caetano, Constantino [1 ]
Morgado, Maria Luisa [2 ,3 ]
Patricio, Paula [4 ,5 ]
Pereira, Joao F. [3 ]
Nunes, Baltazar [1 ,6 ]
机构
[1] Inst Nacl Saude Doutor Ricardo Jorge, P-1649016 Lisbon, Portugal
[2] Univ Lisbon, Inst Super Tecn, Ctr Computat & Stochast Math, P-1049001 Lisbon, Portugal
[3] Univ Tras Os Montes & Alto Douro, Dept Math, UTAD, P-5001801 Vila Real, Portugal
[4] FCT NOVA, Ctr Math & Applicat CMA, P-2829516 Caparica, Portugal
[5] FCT NOVA, Dept Math, P-2829516 Caparica, Portugal
[6] Univ Nova Lisboa, Ctr Invest Saude Publ, Escola Nacl Saude Publ, P-1600560 Lisbon, Portugal
关键词
epidemiological models; SEIR type compartmental model; COVID-19; mathematical modelling; contact matrices; PATTERNS; SPREAD;
D O I
10.3390/math9101084
中图分类号
O1 [数学];
学科分类号
0701 ; 070101 ;
摘要
In this paper, we present an age-structured SEIR model that uses contact patterns to reflect the physical distance measures implemented in Portugal to control the COVID-19 pandemic. By using these matrices and proper estimates for the parameters in the model, we were able to ascertain the impact of mitigation strategies employed in the past. Results show that the March 2020 lockdown had an impact on disease transmission, bringing the effective reproduction number (R(t)) below 1. We estimate that there was an increase in the transmission after the initial lift of the measures on 6 May 2020 that resulted in a second wave that was curbed by the October and November measures. December 2020 saw an increase in the transmission reaching an R(t) = 1.45 in early January 2021. Simulations indicate that the lockdown imposed on the 15 January 2021 might reduce the intensive care unit (ICU) demand to below 200 cases in early April if it lasts at least 2 months. As it stands, the model was capable of projecting the number of individuals in each infection phase for each age group and moment in time.
引用
收藏
页数:16
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