Conformational changes in fibronectin due to adsorption to well-defined surface chemistries

被引：0

作者：

Michael, KE ^{[1
]}

Keselowsky, BG ^{[1
]}

Vernekar, VN ^{[1
]}

Latour, RA ^{[1
]}

García, AJ ^{[1
]}

机构：

[1] Georgia Inst Technol, Coulter Sch Biomed Engn, Atlanta, GA 30332 USA

来源：

SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS: BIOENGINEERING - INTEGRATIVE METHODOLOGIES, NEW TECHNOLOGIES | 2002年

关键词：

adsorption; conformation; integrin;

D O I：

暂无

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

Protein adsorption to surfaces is a complex phenomenon resulting in partial unfolding of the protein thereby changing its structure or conformation. We have shown that changes in the structure of fibronectin (Fn) upon adsorption to surfaces alter the integrin alpha(5)beta(1) binding affinity and modulate subsequent cellular events. [1] This study investigates adsorption-induced conformational changes of a well-characterized recombinant Fn fragment both kinetically and at equilibrium. The work presented here provides a mechanistic understanding of how conformational changes influence integrin binding and subsequent cell function.

引用

页码：601 / 602

页数：2

共 50 条

[41] Synthesis of well-defined catechol polymers for surface functionalization of magnetic nanoparticles
Zhang, Qiang
Nurumbetov, Gabit
Simula, Alexandre
Zhu, Chongyu
Li, Muxiu
Wilson, Paul
Kempe, Kristian
Yang, Bin
Tao, Lei
Haddleton, David M.
POLYMER CHEMISTRY, 2016, 7 (45) : 7002 - 7010
[42] Surface Ordering in Molecular Clusters by Interactions of Well-Defined Parity Multipoles
Cannavacciuolo, Luigi
Hulliger, Juerg
ACS OMEGA, 2019, 4 (17): : 17511 - 17518
[43] Stimuli responsive surface segregation of well-defined end functionalized polymers
Hutchings, Lian R.
Thompson, Richard L.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
[44] Creating Nano-engineered Biomaterials with Well-Defined Surface Descriptors
Visalakshan, Rahul M.
MacGregor, Melanie N.
Cavallaro, Alex A.
Sasidharan, Salini
Bachhuka, Akash
Mierczynska-Vasilev, Agnieszka M.
Hayball, John D.
Vasilev, Krasimir
ACS APPLIED NANO MATERIALS, 2018, 1 (06): : 2796 - 2807
[45] Well-defined surface-bonded ruthenium complexes with molecular nitrogen
Miessner, H
Richter, K
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1998, 37 (1-2) : 117 - 119
[46] Catalysis of Hydrosilylation by Well-Defined Surface Rhodium Siloxide Phosphine Complexes
Marciniec, Bogdan
Szubert, Karol
Potrzebowski, Marek J.
Kownacki, Ireneusz
Maciejewski, Hieronim
CHEMCATCHEM, 2009, 1 (02) : 304 - 310
[47] Surface hydrophilic modification with well-defined glycopolymer for protein imprinting matrix
Yang, Huan
Guo, Tian-Ying
Zhou, Dezhong
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2011, 48 (03) : 432 - 438
[48] Generation of well-defined electrophilic surface sites on sulfated zirconium oxide
Conley, Matthew
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
[49] ADSORPTION OF MOLECULAR NITROGEN ON RHODIUM SUPPORTED ON DEALUMINATED ZEOLITE-Y - THE FORMATION OF WELL-DEFINED SURFACE DINITROGEN COMPLEXES
MIESSNER, H
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (08) : 927 - 928
[50] ORIENTED ADSORPTION AT WELL-DEFINED ELECTRODE SURFACES STUDIED BY AUGER, LEED, AND EELS SPECTROSCOPY
BATINA, N
FRANK, DG
GUI, JY
KAHN, BE
LIN, CH
LU, F
MCCARGAR, JW
SALAITA, GN
STERN, DA
ZAPIEN, DC
HUBBARD, AT
ELECTROCHIMICA ACTA, 1989, 34 (08) : 1031 - 1044

← 1 2 3 4 5 →