Two New Flavonoids from the Nuts of Areca catechu

被引：12

作者：

Yuan, Mengfei ^{[1
]}

Ao, Yunlin ^{[1
]}

Yao, Nan ^{[1
]}

Xie, Jing ^{[1
]}

Zhang, Dongmei ^{[1
]}

Zhang, Jian ^{[1
]}

Zhang, Xiaoqi ^{[1
]}

Ye, Wencai ^{[1
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangdong Prov Engn Res Ctr Modernazat TCM, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 16期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Areca catechu; flavonoids; absolute configuration; cytotoxicity; ALKALOIDS; FLAVONOLIGNANS;

D O I：

10.3390/molecules24162862

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new flavonoids, calquiquelignan M (1), calquiquelignan N (2), along with nine known compounds (3-11), were isolated from the nuts of Areca catechu (Palmae). The new structures, including absolute configurations, were established by a combination of spectroscopic data and electronic circular dichroism (ECD) calculation. The known compounds were identified by comparing their spectroscopic data with reported in the literature. The flavonoids compounds (1-8) were evaluated for their cytotoxicity activities against three human cancer cell lines. Compounds 1 and 2 exhibited a moderate cytotoxic activity against HepG2 cell lines with IC50 values of 49.8 and 53.6 mu M, respectively.

引用

页数：7

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