Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatized subjects

被引：200
|
作者：
Lanius, R. A. [1 ,2 ]
Bluhm, R. L.
Coupland, N. J. [3 ]
Hegadoren, K. M. [4 ]
Rowe, B. [5 ]
Theberge, J. [6 ,7 ,8 ]
Neufeld, R. W. J. [9 ]
Williamson, P. C. [2 ]
Brimson, M.
机构：
[1] Univ Western Ontario, Dept Psychiat, London Hlth Sci Ctr, London, ON N6A 5A5, Canada
[2] Univ Western Ontario, Dept Neurosci, London, ON N6A 5A5, Canada
[3] Univ Alberta, Dept Psychiat, Edmonton, AB, Canada
[4] Univ Alberta, Fac Nursing, Edmonton, AB, Canada
[5] Univ Alberta, Fac Emergency Med, Edmonton, AB, Canada
[6] Univ Western Ontario, Dept Med Imaging & Med Biophys, London, ON N6A 5A5, Canada
[7] St Josephs Hlth Care, Dept Diagnost Imaging, London, ON, Canada
[8] Univ Western Ontario, Lawson Hlth Res Inst, London, ON N6A 5A5, Canada
[9] Univ Western Ontario, Dept Psychol, London, ON N6A 5A5, Canada
来源：
ACTA PSYCHIATRICA SCANDINAVICA | 2010年 / 121卷 / 01期
基金：
加拿大健康研究院;
关键词：
post-traumatic stress disorder; neuroimaging; anxiety; BOLD SIGNAL FLUCTUATIONS; FUNCTIONAL CONNECTIVITY; BRAIN-FUNCTION; POSTERIOR CINGULATE; BASE-LINE; FMRI; STATE; CORTEX; SCALE; SCHIZOPHRENIA;
D O I：
10.1111/j.1600-0447.2009.01391.x
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Objective: The goal of this study was to investigate the relationship between default mode network connectivity and the severity of post-traumatic stress disorder (PTSD) symptoms in a sample of eleven acutely traumatized subjects. Method: Participants underwent a 5.5 min resting functional magnetic resonance imaging scan. Brain areas whose activity positively correlated with that of the posterior cingulate/precuneus (PCC) were assessed. To assess the relationship between severity of PTSD symptoms and PCC connectivity, the contrast image representing areas positively correlated with the PCC was correlated with the subjects' Clinician Administered PTSD Scale scores. Results: Results suggest that resting state connectivity of the PCC with the perigenual anterior cingulate and the right amygdala is associated with current PTSD symptoms and that correlation with the right amygdala predicts future PTSD symptoms. Conclusion: These results may contribute to the development of prognostic tools to distinguish between those who will and those who will not develop PTSD.
引用
收藏
页码：33 / 40
页数：8
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