Principles of RNA methylation and their implications for biology and medicine

被引：89
|
作者：
Zhou, Yujia [1 ,2 ]
Kong, Ying [5 ]
Fan, Wenguo [6 ]
Tao, Tao [4 ]
Xiao, Qin [7 ]
Li, Na [3 ]
Zhu, Xiao [1 ,2 ,8 ,9 ]
机构：
[1] Guangdong Med Univ, Marine Biomed Res Inst, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang, Peoples R China
[2] Marine Biomed Res Inst Guangdong Zhanjiang, Zhanjiang, Peoples R China
[3] Chongqing Med Univ, Coll Basic Med, Chongqing, Peoples R China
[4] Zibo Cent Hosp, Dept Gastroenterol, Zibo, Peoples R China
[5] Jianghan Univ, Dept Clin Lab, Hubei 3 Peoples Hosp, Wuhan, Peoples R China
[6] Sun Yat Sen Univ, Hosp Stomatol, Dept Anesthesiol, Guangzhou, Peoples R China
[7] Peking Univ, Dept Blood Transfus, Shenzhen Hosp, Shenzhen, Peoples R China
[8] Guangdong Med Univ, Key Lab Zhanjiang R&D Marine Microbial Resources, Zhanjiang, Peoples R China
[9] Southern Marine Sci & Engn Guangdong Lab Zhanjian, Zhanjiang, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 131卷
基金：
中国国家自然科学基金;
关键词：
RNA methylation; m6A; Regulators; Biological function; Cancer; HEME OXYGENASE-1 SYSTEM; CANCER STEM-CELLS; MESSENGER-RNA; DEMETHYLASE ALKBH5; HEPATOCELLULAR-CARCINOMA; FAT MASS; GENE-EXPRESSION; BREAST-CANCER; SELF-RENEWAL; NUCLEAR-RNA;
D O I：
10.1016/j.biopha.2020.110731
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
RNA methylation is a post-transcriptional level of regulation. At present, more than 150 kinds of RNA modifications have been identified. They are widely distributed in messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), noncoding small RNA (sncRNA) and long-chain non-coding RNA (lncRNA). In recent years, with the discovery of RNA methylation related proteins and the development of high-throughput sequencing technology, the mystery of RNA methylation has been gradually revealed, and its biological function and application value have gradually emerged. In this review, a large number of research results of RNA methylation in recent years are collected. Through systematic summary and refinement, this review introduced RNA methylation modification-related proteins and RNA methylation sequencing technologies, as well as the biological functions of RNA methylation, expressions and applications of RNA methylation-related genes in physiological or pathological states such as cancer, immunity and virus infection, and discussed the potential therapeutic strategies.
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页数：22
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