NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant

被引：22
|
作者：
Yao, Wei-Wei [1 ,2 ]
Li, Ran [1 ,2 ]
Li, Jiang-Fei [1 ,2 ]
Sun, Juan [3 ]
Ye, Mengchun [1 ,2 ]
机构：
[1] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China
[2] Nankai Univ, Coll Chem, Inst Elernentoorgan Chem, Tianjin 300071, Peoples R China
[3] Nankai Univ, Coll Chem, Key Lab Adv Energy Mat Chem, Dept Chem, Tianjin 300071, Peoples R China
来源：
GREEN CHEMISTRY | 2019年 / 21卷 / 09期
基金：
中国国家自然科学基金;
关键词：
BOND-FORMING HYDROGENATION; ASYMMETRIC TRANSFER HYDROGENATION; NICKEL CATALYSIS; ALLYLIC ALCOHOLS; 2+2+2 CYCLOADDITION; CONJUGATED ALKYNES; AZA-NICKELACYCLE; ALDEHYDES; CARBONYL; AMINES;
D O I：
10.1039/c9gc00653b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A nickel-catalyzed reductive coupling of alkynes and imines using readily available isopropanol as the reducing agent was developed. The use of a sterically bulky and electron-rich carbene ligand (AnIPr) significantly promotes the reaction, providing various multi-substituted allylic amines in 23-89% yield and the corresponding chiral ligand (AnIPr-3) can afford the products in 51-95% ee.
引用
收藏
页码：2240 / 2244
页数：5
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