Production of transgenic mice with yeast artificial chromosomes

被引：44
|
作者：
Peterson, KR
Clegg, CH
Li, QL
Stamatoyannopoulos, G
机构：
[1] UNIV WASHINGTON, DEPT GENET, SEATTLE, WA 98195 USA
[2] BRISTOL MYERS SQUIBB PHARMACEUT RES INST, SEATTLE, WA 98121 USA
来源：
TRENDS IN GENETICS | 1997年 / 13卷 / 02期
关键词：
D O I：
10.1016/S0168-9525(97)01003-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Techniques are now available that allow the transfer of intact yeast artificial chromosome (YAC) DNA into transgenic mice. Coupled with the ability to perform mutagenesis on YAC sequences by homologous recombination in yeast, they enable the analysis of large genes or multigenic loci in vivo. This system has been used to study the developmental regulation of the human beta-globin locus.
引用
收藏
页码：61 / 66
页数：6
相关论文
共 50 条
  • [41] RESCUE OF END FRAGMENTS OF YEAST ARTIFICIAL CHROMOSOMES BY HOMOLOGOUS RECOMBINATION IN YEAST
    HERMANSON, GG
    HOEKSTRA, MF
    MCELLIGOTT, DL
    EVANS, GA
    NUCLEIC ACIDS RESEARCH, 1991, 19 (18) : 4943 - 4948
  • [42] Production of transgenic mice
    Jean Richa
    Molecular Biotechnology, 2001, 17 : 261 - 268
  • [43] Production of transgenic mice
    Richa, J
    MOLECULAR BIOTECHNOLOGY, 2001, 17 (03) : 261 - 268
  • [44] PRODUCTION OF TRANSGENIC MICE
    GORDON, JW
    GUIDE TO TECHNIQUES IN MOUSE DEVELOPMENT, 1993, 225 : 747 - 771
  • [45] Double-strand breaks on artificial chromosomes in yeast
    Ross, LO
    Zenvirth, D
    Jardim, AR
    Dawson, D
    CHROMOSOMA, 2000, 109 (04) : 226 - 234
  • [46] Double-strand breaks on artificial chromosomes in yeast
    Lyle O. Ross
    Drora Zenvirth
    Ana Rita Jardim
    Dean Dawson
    Chromosoma, 2000, 109 : 226 - 234
  • [47] GENOME MAPPING BY ARBITRARY AMPLIFICATION OF YEAST ARTIFICIAL CHROMOSOMES
    DIRIENZO, A
    PETERSON, A
    DAS, S
    FREIMER, NB
    MAMMALIAN GENOME, 1993, 4 (07) : 359 - 363
  • [48] CHROMOSOMAL INSITU HYBRIDIZATION USING YEAST ARTIFICIAL CHROMOSOMES
    SELLERI, L
    HERMANSON, GG
    EUBANKS, JH
    EVANS, GA
    GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING, 1991, 8 (02): : 59 - 66
  • [49] CLONING OF THE HUNTINGTON DISEASE REGION IN YEAST ARTIFICIAL CHROMOSOMES
    ZUO, J
    ROBBINS, C
    TAILLONMILLER, P
    COX, DR
    MYERS, RM
    HUMAN MOLECULAR GENETICS, 1992, 1 (03) : 149 - 159
  • [50] A RAPID PROCEDURE FOR THE COMPOSITIONAL ANALYSIS OF YEAST ARTIFICIAL CHROMOSOMES
    DESARIO, A
    GEIGL, EM
    BERNARDI, G
    NUCLEIC ACIDS RESEARCH, 1995, 23 (19) : 4013 - 4014
12345