Production of transgenic mice with yeast artificial chromosomes

被引：44
|
作者：
Peterson, KR
Clegg, CH
Li, QL
Stamatoyannopoulos, G
机构：
[1] UNIV WASHINGTON, DEPT GENET, SEATTLE, WA 98195 USA
[2] BRISTOL MYERS SQUIBB PHARMACEUT RES INST, SEATTLE, WA 98121 USA
来源：
TRENDS IN GENETICS | 1997年 / 13卷 / 02期
关键词：
D O I：
10.1016/S0168-9525(97)01003-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Techniques are now available that allow the transfer of intact yeast artificial chromosome (YAC) DNA into transgenic mice. Coupled with the ability to perform mutagenesis on YAC sequences by homologous recombination in yeast, they enable the analysis of large genes or multigenic loci in vivo. This system has been used to study the developmental regulation of the human beta-globin locus.
引用
收藏
页码：61 / 66
页数：6
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