Spectroscopic Assignments and Reference Data of a Pyrrolo[2,1-a]isoquinoline

被引：0
|
作者：
Zhang, Xiaohui [1 ]
Jin, Yueshuang [1 ]
Wang, Ailing [1 ]
Li, Depeng [1 ]
You, Yecheng [1 ]
机构：
[1] Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
来源：
PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2 | 2009年
关键词：
NMR; Pyrrolo[2,1-a]isoquinoline;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The structure elucidation of natural products, relies heavily on the application of proton detected heteronuclear NMR spectroscopy. Systematic assignment of proton and carbon signals of a natural product can be firmly established by examination of DEPT, COSY, NOESY, HMBC and HSQC measurements. Reported here is the product of the reaction of papaverine with 2,4,5-trimethoxy-alpha-bromo-acetophenone being 1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-2-(2,4,5-trimetho-xyphenyl)pyrrolo[2,1-a]isoquinoline (1). This system is the skeleton of Lamerallin H and its derivatives, which exhibit interesting and significant biological properties. The structure of was clearly elucidated by examination of its IR, MS, and NMR (H-1, C-13, DEPT-135, COSY, NOESY, TOCSY, HMBC and HSQC) spectra.
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页码：647 / 651
页数：5
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