A Facile Synthesis of N-Aryl Substituted Piperidones

被引：2

作者：

Geng Qian ^{[1
]}

Zhang Hui ^{[1
]}

Cao Weiguo ^{[1
,2
,3
]}

Chen Yali ^{[1
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2009年 / 27卷 / 10期

基金：

中国国家自然科学基金;

关键词：

N-aryl; 4-piperidone; Ullmann amination; ligand; copper(I) iodide; ONE-POT SYNTHESIS; COUPLING REACTIONS; BOND FORMATION; CONVENIENT SYNTHESIS; ASYMMETRIC-SYNTHESIS; AMINO-ACID; ARYLATION; ULLMANN; IODIDES; HETEROCYCLES;

D O I：

10.1002/cjoc.200990335

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general and efficient procedure for the synthesis of N-aryl-substituted 4-piperidones was developed. The two step syntheses proceeded with an overall yield of 60%-83% using L-proline as the ligand for the Cu(I)-catalyzed Ullmann amination followed by subsequent hydrolysis of resulting ketals.

引用

页码：1995 / 2000

页数：6

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