B cell memory: understanding COVID-19

被引：96
|
作者：
Quast, Isaak [1 ]
Tarlinton, David [1 ]
机构：
[1] Monash Univ, Dept Pathol & Immunol, 89 Commercial Rd, Melbourne, Vic 3004, Australia
来源：
IMMUNITY | 2021年 / 54卷 / 02期
基金：
瑞士国家科学基金会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
D O I：
10.1016/j.immuni.2021.01.014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunological memory is a mechanism to protect us against reinfection. Antibodies produced by B cells are integral to this defense strategy and underlie virtually all vaccine success. Here, we explain how B cell memory is generated by infection and vaccination, what influences its efficacy and its persistence, and how characterizing these parameters in the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will help achieve protective immunity through vaccination.
引用
收藏
页码：205 / 210
页数：6
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