Antihyperlipidemic Compounds from the Fruit of Piper longum L.

被引:49
|
作者
Jin, Zhuang [1 ]
Borjihan, Gereltu [1 ]
Zhao, Ruiguo [1 ]
Sun, Zhaorigetu [1 ]
Hammond, Gerald B. [2 ]
Uryu, Toshiyuki [3 ]
机构
[1] Inner Mongolia Univ, Inst Macromol Chem & Mongolian Med, Hohhot 010021, Peoples R China
[2] Univ Louisville, Dept Chem, Louisville, KY 40292 USA
[3] Teikyo Univ Sci & Technol, Yamanashi 4090193, Japan
关键词
antihyperlipidemic activity; Piper longum L; piperlonguminine; piperine; piperonaline; RATS; REDUCTASE;
D O I
10.1002/ptr.2630
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码:1194 / 1196
页数:3
相关论文
共 50 条
  • [11] Isolation and Characterization of Antidermatophytic Bioactive Molecules from Piper longum L. Leaves
    Jayshree Das
    D. K. Jha
    R. S. Policegoudra
    Afjal Hussain Mazumder
    Mrinmoy Das
    P. Chattopadhyay
    L. Singh
    Indian Journal of Microbiology, 2012, 52 : 624 - 629
  • [12] Isolation and Characterization of Antidermatophytic Bioactive Molecules from Piper longum L. Leaves
    Das, Jayshree
    Jha, D. K.
    Policegoudra, R. S.
    Mazumder, Afjal Hussain
    Das, Mrinmoy
    Chattopadhyay, P.
    Singh, L.
    INDIAN JOURNAL OF MICROBIOLOGY, 2012, 52 (04) : 624 - 629
  • [13] Sesquiterpenes from the fruits of Piper longum L. and their anti-inflammatory activity
    Gou, Guanghui
    Xu, Nannan
    Li, Hongliang
    Li, Jun
    Aisa, Haji Akber
    FITOTERAPIA, 2024, 179
  • [14] Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L. on Permanent Focal Cerebral Ischemia Injury in Rats
    Hua, Shiyao
    Wang, Bing
    Chen, Rong
    Zhang, Yuanbin
    Zhang, Yiwei
    Li, Tingting
    Dong, Lin
    Fu, Xueyan
    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2019, 28 (03): : 751 - 760
  • [15] Genetic variation and micropropagation in three varieties of Piper longum L.
    Philip, Shaji
    Banerjee, N.S.
    Das, M.R.
    2000, Indian Academy of Sciences (78):
  • [16] Genetic variation and micropropagation in three varieties of Piper longum L.
    Philip, S
    Banerjee, NS
    Das, MR
    CURRENT SCIENCE, 2000, 78 (02): : 169 - 173
  • [17] Antiinflammatory Activity of Piper longum Fruit Oil
    Kumar, A.
    Panghal, S.
    Mallapur, S. S.
    Kumar, M.
    Ram, Veerma
    Singh, B. K.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 71 (04) : 454 - U179
  • [18] Piperlongosides A-C, Three New Phenolic Constituents From Piper longum L.
    Huyen, Le Thi
    Hau, Nguyen Thi Thu
    Kiem, Phan Van
    NATURAL PRODUCT COMMUNICATIONS, 2023, 18 (01)
  • [19] Insights into the functional potential of bacterial endophytes from the ethnomedicinal plant, Piper longum L.
    Laccy Phurailatpam
    Amrita Gupta
    Pramod Kumar Sahu
    Sushma Mishra
    Symbiosis, 2022, 87 : 165 - 174
  • [20] Identification of Piper longum L. from Different Areas by FTIR and HPLC Fingerprint Methods
    Zhang Hui-wen
    Song Xiao-ling
    Shi Song-li
    Zhang Sha-sha
    Liang Yue
    Wang Huan-yun
    SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40 (01) : 174 - 178