LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the Pl3K/AKT pathway

被引：42

作者：

Li, ZhiZhen ^{[1
,2
,3
]}

Chen, YuanYuan ^{[1
,2
,3
]}

Wang, XuAn ^{[1
,2
,3
]}

Zhang, HongChen ^{[1
,2
,3
]}

Zhang, Yijian ^{[1
,2
,3
]}

Gao, YaoHui ^{[1
,2
,3
]}

Weng, Mingzhe ^{[1
,2
,3
]}

Wang, Lei ^{[1
,2
,3
]}

Liang, HaiBin ^{[1
,2
,3
]}

Li, MaoLan ^{[1
,2
,3
]}

Zhang, Fei ^{[1
,2
,3
]}

Zhao, Shuai ^{[1
,2
,3
]}

Liu, Shibo ^{[1
,2
,3
]}

Cao, Yang ^{[1
,2
,3
]}

Shu, Yijun ^{[1
,2
,3
]}

Bao, Runfa ^{[1
,2
,3
]}

Zhou, Jian ^{[1
,2
,3
]}

Liu, Xiyong ^{[1
,2
,3
]}

Yan, Yun ^{[1
,2
,3
]}

Zhen, Lei ^{[1
,2
,3
]}

Dong, Qian ^{[1
,2
,3
]}

Liu, Yingbin ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gen Surg, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Lab Gen Surg, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Inst Biliary Tract Dis Res, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China

来源：

CANCER LETTERS | 2016年 / 372卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Gallbladder cancer; LASP-1; S100P; Proliferation; Metastasis; Cell cycle; SH3; PROTEIN-1; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; BREAST-CANCER; SNP DISCOVERY; MIGRATION; SURVIVAL; LIM; OVEREXPRESSION; LOCALIZATION;

D O I：

10.1016/j.canlet.2016.01.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

LASP-1 is an actin-binding protein that regulates cytoskeletal dynamics and cell migration. LASP-1 was previously identified in a cDNA library from metastatic breast cancer samples. This protein has since been detected in multiple human cancers, including liver cancer, gastric cancer and pancreatic cancer. S100P is a small calcium-binding protein in the 5100 protein family that regulates cellular, physiological and pathological processes in various cancers. However, the clinical significance of LASP-1 and S100P expression in gallbladder cancer (GBC) is not yet clear. In our study, we focused on the clinical significance, biological function and mechanism of LASP-1 in gallbladder cancer and detected LASP-1 and S100P overexpression in GBC tissues. The expression of LASP-1 was significantly correlated with poor prognosis in GBC patients (P < 0.05). Furthermore, down-regulation of LASP-1 expression resulted in the obvious inhibition of proliferation and migration and caused cell cycle arrest by down-regulating S100P via the PI3K/AKT pathway; in mice, tumor volume was signifidantly decreased. In conclusion, LASP-1 may act as an oncogene to regulate the expression of S100P to influence cellular functions in GBC. LASP-1 could serve as a genetic treatment target in GBC patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：239 / 250

页数：12

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