Ruthenium(II) 1,4,7-trithiacyclononane complexes of curcumin and bisdemethoxycurcumin: Synthesis, characterization, and biological activity

被引：5

作者：

Pettinari, Riccardo ^{[1
]}

Marchetti, Fabio ^{[2
]}

Tombesi, Alessia ^{[2
]}

Duan, Fenghe ^{[1
]}

Zhou, Liming ^{[3
]}

Messori, Luigi ^{[4
]}

Giacomelli, Chiara ^{[5
]}

Marchetti, Laura ^{[5
]}

Trincavelli, Maria Letizia ^{[5
]}

Marzo, Tiziano ^{[5
]}

La Mendola, Diego ^{[5
]}

Balducci, Gabriele ^{[6
]}

Alessio, Enzo ^{[6
]}

机构：

[1] Univ Camerino, Sch Pharm, Via S Agostino 1, I-62032 Camerino, MC, Italy

[2] Univ Camerino, Sch Sci & Technol, Via S Agostino 1, I-62032 Camerino, MC, Italy

[3] Zhengzhou Univ Light Ind, Henan Prov Key Lab Surface & Interface Sci, Zhengzhou 450002, Peoples R China

[4] Univ Florence, Dept Chem, Via Lastruccia 3-13, Florence, Italy

[5] Univ Pisa, Dept Pharm, Via Bonanno Pisano 6, I-56126 Pisa, Italy

[6] Univ Trieste, Dept Chem & Pharmaceut Sci, Via Giorgieri 1, Trieste, Italy

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2021年 / 218卷

关键词：

Curcumin; Bisdemethoxycurcumin; Ruthenium complexes; 1; 4; 7-trithiacyclononane; Anticancer activity; Metal complexes interaction with protein; lysozyme; HALF-SANDWICH;

D O I：

10.1016/j.jinorgbio.2021.111387

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two cationic ruthenium(II) 1,4,7-trithiacyclononane ([9]aneS3) complexes of curcumin (curcH) and bisdemethoxycurcumin (bdcurcH), namely [Ru(curc)(dmso-S)([9]aneS3)]Cl (1) and [Ru(bdcurc)(dmso-S)([9]aneS3)]Cl (2) were prepared from the [RuCl2(dmso-S)([9]-aneS3)] precursor and structurally characterized, both in solution and in the solid state by X-ray crystallography. The corresponding PTA complexes [Ru(curc)(PTA)([9] aneS3)]Cl (3) and [Ru(bdcurc)(PTA)([9]aneS3)]Cl (4) have been also synthesized and characterized (PTA = 1,3,5-triaza-7-phosphaadamantane). Bioinorganic studies relying on mass spectrometry were performed on complexes 1?4 to assess their interactions with the model protein lysozyme. Overall, a rather limited reactivity with lysozyme was highlighted accompanied by a modest cytotoxic potency against three representative cancer cell lines. The moderate pharmacological activity is likely connected to the relatively high stability of these complexes.

引用

页数：7

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